منابع مشابه
Direct reversal of DNA alkylation damage.
3.5.1. Alkylation Chemotherapy 10 3.5.2. Inhibition of hAGT by O6-Benzylguanine 10 3.5.3. Developing More Potent Inhibitors 10 3.6. Application of hAGT in Biotechnology 10 3.6.1. Quantification of AGT 10 3.6.2. Radioactive Imaging of Tumors 11 3.6.3. hAGT Fusion Proteins in Biotechnology 11 4. AlkB Proteins 11 4.1. Oxidative Dealkylation by AlkB 11 4.1.1. E. Coli AlkB 11 4.1.2. Puzzle of AlkB 1...
متن کاملRepair of triplex-directed DNA alkylation by nucleotide excision repair.
Triplex-forming oligonucleotides (TFOs) are being investigated as highly specific DNA binding agents to inhibit the expression of clinically relevant genes. So far, they have been shown to inhibit transcription from the HER-2/neu gene in vitro, whereas their use in vivo has been studied to a limited extent. This study uses a TFO-chlorambucil (chl) conjugate capable of forming site-specific cova...
متن کاملOGG1 DNA Repair Gene Polymorphism As a Biomarker of Oxidative and Genotoxic DNA Damage
Background: Single nucleotide polymorphisms in 8-oxoguanine DNA glycosylase-1 (OGG1) gene modulates DNA repair capacity and functions as one of the first lines of protective mechanisms against 8-hydroxy-2’-deoxyguanosine (8-OHdG) mutagenicity. OGG1-Cys326 gene polymorphism may decrease DNA repair function, causing oxidative stress due to higher oxidative DNA damage. The main purpose of this stu...
متن کاملPostreplication repair of alkylation damage to DNA of mammalian cells in culture.
Incorporation and alkaline sucrose sedimentation studies of DNA from mouse L-cells have demonstrated the following effects of N-methyl-N-nitrosourea (MNU) and methyl methanesulfonate (MMS). Increasing the concentration of both agents increases the number of single-strand breaks or alkali-labile lesions of existing DNA, which affects the incorporation of [3H]thymidine into DNA by reducing its re...
متن کاملPostreplication Repair of Alkylation Damage to DNA of Mammalian Cells in Culture I
Incorporation and alkaline sucrose sedimentation studies of DNA from mouse L-cells have demonstrated the following effects of N-methyI-N-nitrosourea (MNU) and methyl methanesulfonate (MMS). Increasing the concentration of both agents increases the number of single-strand breaks or alkali-labile lesions of existing DNA, which affects the incorporation of [~H]thymidine into DNA by reducing its re...
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ژورنال
عنوان ژورنال: Acta Biochimica Polonica
سال: 1998
ISSN: 1734-154X,0001-527X
DOI: 10.18388/abp.1998_4333